The selection or elimination of germ cells during development
We are using lineage-tracing approaches to understand the clonal dynamics of primordial germ cells as they relate to behaviors such as migration, proliferation and apoptosis.
We are using lineage-tracing approaches to understand the clonal dynamics of primordial germ cells as they relate to behaviors such as migration, proliferation and apoptosis.
Determinants of the ovarian reserve
We are using mouse genetics and imaging approaches to understand how the development of oocytes in the fetus affects the size of the ovarian reserve as well as the competence of the eggs to produce embryos.
We are using mouse genetics and imaging approaches to understand how the development of oocytes in the fetus affects the size of the ovarian reserve as well as the competence of the eggs to produce embryos.
Quantitative imaging and mathematical modeling of development
We develop tools for the study of germ cells in the embryo and postnatal gonad.
We develop tools for the study of germ cells in the embryo and postnatal gonad.
Epigenetics and Environment in germ cell development
A current project in the lab concerns the effects of common chemicals on developing germ cells and their ‘memories’ of exposures.
A current project in the lab concerns the effects of common chemicals on developing germ cells and their ‘memories’ of exposures.